Hello everyone,
Iām Sam Believ, founder of LaWayra Retreat near Medellin, Colombia. Anxiety is a pervasive and often debilitating condition that affects many people worldwide. Today, I want to discuss how ayahuasca might offer relief for those struggling with anxiety.
Ayahuasca, a traditional Amazonian brew, has been gaining attention for its potential to ease anxiety. A 2021 study found that a single dose of ayahuasca significantly reduced symptoms of social anxiety in participants. This suggests that ayahuasca could offer a new avenue for those struggling with anxiety disorders.
People who’ve used ayahuasca report feelings of greater happiness, optimism, and self-acceptance. These positive mental health changes indicate that ayahuasca may help alleviate anxiety symptoms. However, it’s important to remember that ayahuasca is a powerful psychedelic and isn’t without risks.
Common side effects include nausea, vomiting, and hallucinations, which can be intense and frightening. Despite these potential downsides, the uplifting mental health benefits could make ayahuasca a valuable option for managing anxiety.
Understanding Ayahuasca
Ayahuasca is a traditional Amazonian brew with both spiritual and medicinal uses. Its primary ingredients, Psychotria viridis and Banisteriopsis caapi, give it unique effects.
Origins and Traditional Use
Ayahuasca has been used for centuries by indigenous cultures in the Amazon Basin. It serves as a key part of their spiritual and healing practices. In the 1930s, Brazilian syncretic religions adopted the tea as a sacrament. These traditions view Ayahuasca as a bridge to connect with spiritual realms.
Indigenous healers, called shamans, typically lead Ayahuasca ceremonies. Participants often seek guidance, healing, or insight. The beverage is believed to help with mental clarity and emotional healing. Traditional use revolves around rituals that are deeply ingrained in the culture.
Main Components and Effects
Ayahuasca is primarily made from Psychotria viridis leaves and Banisteriopsis caapi vines. P. viridis contains DMT (dimethyltryptamine), a powerful hallucinogen. B. caapi has MAOIs (monoamine oxidase inhibitors) that allow DMT to be orally active. This combination results in intense psychedelic experiences.
The effects of Ayahuasca can last between 4 to 6 hours. Users often report vivid visual and auditory hallucinations, heightened emotions, and profound introspection. Studies suggest Ayahuasca may reduce activity in the brain’s fear centers, potentially helping with anxiety and depression. Users also note a sense of connection and spiritual awakening.
Anxiety Disorders: An Overview

Anxiety disorders are among the most common mental health conditions, affecting millions of people worldwide. They can manifest in various forms, each having its unique set of causes and symptoms.
Types of Anxiety Disorders
There are several types of anxiety disorders, each with its own characteristics. Generalized Anxiety Disorder (GAD) involves persistent and excessive worry about everyday things. People may feel restless and have concentration problems.
Panic Disorder
features sudden, intense episodes of fear known as panic attacks. These attacks can include heart palpitations, sweating, and dizziness.
Social Anxiety Disorder
causes extreme fear of social situations. This can lead to avoidance of social interactions and significant distress.
Specific Phobias
involve intense fear of particular objects or situations, like heights or spiders. These fears are often irrational but can severely limit a person’s activities.
Post-Traumatic Stress Disorder (PTSD)
occurs after experiencing or witnessing traumatic events. Symptoms include flashbacks, nightmares, and severe anxiety.
Obsessive-Compulsive Disorder (OCD)
features unwanted, persistent thoughts (obsessions) and repetitive behaviors (compulsions).
Causes and Symptoms
The causes of anxiety disorders are multifaceted. Genetics play a role, as these conditions often run in families. Brain chemistry and stress are also significant factors. Traumatic events can trigger anxiety in some individuals.
Symptoms vary depending on the type of anxiety disorder. Common symptoms include excessive worry, restlessness, fatigue, difficulty concentrating, muscle tension, and sleep disturbances.
Physical symptoms can also occur, such as accelerated heart rate, sweating, trembling, and gastrointestinal issues. These symptoms can interfere with daily life, affecting work, school, and personal relationships.
Effective treatment often involves therapy, medication, or a combination of both. Early intervention can greatly improve outcomes.
Scientific Research on Ayahuasca and Anxiety
Research shows that ayahuasca has potential in reducing anxiety. Clinical studies and neuroscientific findings provide insights into its possible benefits and mechanisms.
āIt wasnāt like the anxiety disappeared instantly,ā shared podcast guest Gabriela CĆ”rdenas, ābut I finally understood where it came from. That changed how I related to it. I stopped fighting and started listening, and that made all the difference.ā
Clinical Studies
Several clinical studies have explored the effects of ayahuasca on anxiety. One study found that participants who used ayahuasca reported significant reductions in anxiety symptoms. More than 80% showed improvements that lasted for months.
Another large survey indicated that symptoms of anxiety were “very much” or “completely” improved in most users. This suggests that ayahuasca could offer lasting relief for many.
Despite these promising results, more research is needed. Current studies have small sample sizes and rely on self-reported data, which can be subjective.
Neuroscientific Findings
Neuroscientific research offers insights into how ayahuasca affects anxiety. It may work by interacting with serotonin receptors in the brain, which are involved in mood regulation.
Ayahuasca contains DMT, a compound believed to create intense emotional and psychological experiences. These experiences can lead to lasting changes in brain function, potentially reducing anxiety.
Another mechanism may involve the reduction of chronic inflammation and oxidative stress. Ayahuasca’s impact on these biological processes could help alleviate anxiety symptoms.
Scientific research in this area is ongoing, with future studies aimed at better understanding these mechanisms.
Therapeutic Potential of Ayahuasca

Ayahuasca, a traditional Amazonian brew, has been studied for its potential to alleviate symptoms of anxiety and other mental health conditions. Key areas include its unique mechanisms of action and how it can be integrated into therapeutic practice.
āThere was a moment in ceremony where all the noise in my head justā¦quieted,ā said Pablo Quintero. āIt didnāt stay silent forever, but it gave me a reference point of peace. Since then, I know itās possible to return there.ā
Mechanisms of Action
Ayahuasca contains substances like DMT and harmine. DMT is a powerful psychedelic that can alter perception and mood. Harmine and other compounds in the brew inhibit enzymes that break down neurotransmitters, allowing for prolonged effects.
Research suggests that these components work together to influence the brain’s serotonin system. This system plays a significant role in mood regulation, which may explain some of the brew’s reported antidepressant and anxiolytic effects.
Ayahuasca also stimulates brain regions related to emotion and self-awareness. This can lead to profound insights and emotional breakthroughs, which many users find therapeutic. Neuroimaging studies have shown increased activity in the brain’s default mode network, which is often associated with self-referential thoughts and mental clarity.
Integration into Therapy
The communal aspect of ayahuasca ceremonies can enhance its therapeutic potential. Participants usually consume the brew in guided sessions, often with a shaman or therapist present. This setting can provide a sense of security and community.
Incorporating ayahuasca into therapy involves more than just drinking the brew. Preparation and integration sessions are crucial. Preparation includes setting goals and understanding potential experiences, while integration helps process and apply insights gained during the session.
āWhat helped me wasnāt just the ayahuasca,ā noted Irene Villegas, ābut the way the whole process was supported. Talking about what I felt, mapping it back to my life, and realizing Iād been living in fear loops without knowingāit gave me tools I still use today.ā
Therapists often use techniques like talk therapy or cognitive behavioral therapy alongside ayahuasca to maximize benefits. The altered state of consciousness induced by the brew can open up new avenues for treatment, allowing individuals to confront deeply rooted issues.
Combining these traditional practices with modern therapeutic approaches may offer a unique and potent form of healing for anxiety and other conditions.
Safety and Legal Considerations
Ayahuasca has various physical and psychological risks, and its legal status varies widely across the world. It’s crucial to be well-informed on these fronts before considering its use.
Physical and Psychological Risks
Ayahuasca may pose serious risks to both physical and mental health. The brew often raises blood pressure, which can be dangerous for people with heart conditions. In addition, it might cause digestive upset, leading to vomiting and diarrhea.
Psychological risks include intense hallucinations and emotional distress. Some users have reported worsening of mental health conditions. For instance, a small minority with anxiety or depression experienced their symptoms becoming more severe.
It’s also important to note that those with a history of certain conditions such as diabetes, kidney issues, or liver problems should avoid ayahuasca. Proper mental preparation and a safe environment can help reduce but not eliminate these risks.
Legal Status Worldwide
The legality of ayahuasca varies by country. In Brazil and Peru, it is generally legal and often used in traditional ceremonies. This cultural acceptance provides a structured and respectful environment.
In the United States, ayahuasca is considered a Schedule I substance, making it illegal. However, some religious organizations have gained legal exemptions to use it in ceremonies.
Some countries have grey areas regarding its legality. For instance, while not explicitly legal, certain ayahuasca retreats may operate in countries like Costa Rica and Ecuador.
It’s important to research the laws in your specific location and understand the legal implications of participating in ayahuasca ceremonies.
Personal Experiences and Anecdotal Evidence

Many individuals have shared their personal experiences with ayahuasca, especially regarding its effects on anxiety. These stories, while not scientifically verified, offer valuable insights.
āI was nervous and anxious before arriving at LaWayra, but the environment and people helped me feel grounded. After the ceremonies, I found a calmness inside that Iād never experienced before.ā
ā Lizette Hayman
Some people report that ayahuasca sessions helped them gain deep personal insights and clarity on their issues. They claim this newfound perspective led to a reduction in anxiety symptoms.
Others describe the experience as emotionally intense. During the sessions, individuals often process deeply buried emotions and traumas. This can sometimes result in temporary emotional discomfort, which many believe is a necessary step toward healing.
Although a minority of users report worsening anxiety, a larger number claim long-lasting benefits. They state that they feel calmer and more balanced in their daily lives.
The role of the shaman or guide is crucial in these experiences. A skilled guide can help participants navigate their experiences, ensuring safety and support.
Communal or group sessions are common. Participants often feel a strong sense of community and shared purpose, which can contribute to the therapeutic effects.
While these personal stories are compelling, they should be considered with caution. Not every individual will have the same experience, and self-reports can be highly subjective.
āBefore LaWayra, anxiety was always in the driverās seat. The experience helped me reset how I relate to fear. Now I feel more in controlānot because the fear is gone, but because I understand it.ā
ā Charlotte Truyens
Challenges and Limitations of Current Research
Research on ayahuasca’s effects on anxiety faces several challenges. One issue is the limited sample sizes in many studies. Small groups can lead to results that aren’t generalizable to a larger population.
Another challenge is the variability in dosages and administration settings. Studies often use different amounts of ayahuasca and different environments, leading to inconsistent results.
The lack of long-term studies is also a problem. Most research focuses on short-term effects, leaving questions about the long-term impact of ayahuasca on anxiety.
Moreover, ethical and legal barriers complicate research efforts. Ayahuasca’s legal status varies globally, making it difficult to conduct large-scale studies in some regions.
Finally, there is a need for rigorous clinical trials. Many studies so far are observational or based on self-reported data, which can introduce biases.
In summary, these challenges must be addressed to fully understand ayahuasca’s potential for treating anxiety.
Alternatives to Ayahuasca for Anxiety Relief

There are several alternatives to ayahuasca for managing anxiety. These options can be medicinal, therapeutic, or lifestyle-based, providing different approaches to anxiety relief.
Medications
Antidepressants like SSRIs (e.g., fluoxetine, sertraline) are often prescribed for anxiety.
Benzodiazepines (e.g., lorazepam, diazepam) are effective but may cause dependence.
Beta-blockers (e.g., propranolol) help manage physical symptoms of anxiety.
Therapy
Cognitive Behavioral Therapy (CBT) helps change negative thought patterns.
Exposure Therapy gradually exposes patients to anxiety triggers.
Mindfulness-Based Stress Reduction (MBSR) focuses on meditation and awareness techniques.
Lifestyle Changes
Exercise can reduce anxiety by releasing endorphins.
Healthy Diet rich in nutrients supports brain health.
Adequate Sleep is crucial for mental well-being.
Alternative Therapies
Herbal Supplements like valerian root, kava, and chamomile are popular.
Aromatherapy using lavender or chamomile oils can be calming.
Yoga combines physical activity and meditation for stress relief.
Support Systems
Support Groups offer community and understanding.
Family and Friends provide emotional support and encouragement.
By exploring these alternatives, individuals can find effective ways to manage their anxiety without relying on ayahuasca.
Conclusion and Future Perspectives
Ayahuasca has shown promise in helping reduce anxiety symptoms. Several studies indicate significant improvements in mental health and quality of life among users.
The Amazonian brew has been traditionally used for spiritual and healing purposes. Recent interest in its potential for treating anxiety highlights the need for more scientific investigations.
Further research is essential. Large-scale, placebo-controlled studies could provide more robust evidence. This will help determine the exact mechanisms by which ayahuasca affects anxiety.
Researchers should also explore long-term effects. Understanding if benefits are lasting or temporary will be crucial for developing therapeutic protocols.
The role of set and setting should not be overlooked. Factors such as the environment in which ayahuasca is consumed, and the mental state of the individual, play a significant role in outcomes.
Clinicians and policymakers need to consider safety. Setting regulatory frameworks to ensure safe use can prevent potential misuse and adverse effects.
Ethical considerations are important. Respect for Indigenous traditions and knowledge is essential in integrating ayahuasca into modern therapeutic practices.
Community involvement will be beneficial. Collaboration with Indigenous communities could offer valuable insights into traditional uses and preparation methods.
The future of ayahuasca research is promising. With proper methodologies and ethical guidelines, it can potentially become a valuable tool in mental health treatment.
Continued dialogue between scientists, clinicians, and traditional healers can foster an inclusive approach. This can lead to culturally sensitive and scientifically sound practices in ayahuasca use.
Frequently Asked Questions
This section addresses common concerns about using ayahuasca for anxiety, including its potential effects, psychological impacts, and interactions with conventional treatments.
Can ayahuasca exacerbate symptoms of anxiety in some individuals?
Ayahuasca may cause increased anxiety in certain people, especially during the intense experiences it can provoke. Each person’s reaction to the substance can vary, and it’s essential to approach it with caution and proper guidance.
How does ayahuasca impact anxiety and depression when used together?
Ayahuasca has shown promise in alleviating symptoms of both anxiety and depression. For some, it provides significant relief, while others may find the experience too intense. Combining ayahuasca with supportive practices and a safe setting can enhance its positive effects.
What are the potential psychological effects experienced after an ayahuasca retreat?
Participants often report a range of psychological effects post-retreat. These can include improved mood, heightened self-awareness, and insight into personal issues. Some may also experience lingering anxiety or emotional turbulence, which typically requires time and integration to process.
Are there any studies on the effectiveness of ayahuasca in treating depression?
Several studies suggest that ayahuasca has potential benefits for treating depression. Research involving thousands of users indicates significant improvements in depressive symptoms for many, though individual results can vary widely.
How do ayahuasca and conventional antidepressants interact?
Combining ayahuasca with conventional antidepressants can be risky due to potential interactions. It’s crucial for individuals taking antidepressants to consult with healthcare providers before considering ayahuasca to avoid adverse effects.
Can the use of ayahuasca lead to insomnia or affect sleep patterns?
Ayahuasca use may disrupt sleep patterns for some individuals. While some report better sleep post-experience, others may encounter insomnia or restless nights. Sleep disturbances usually diminish as the body and mind integrate the experience.

A Final Word From The Founder Of LaWayra Regarding about Anxiety Disorder and Ayahuasca Usage
Anxiety disorders involve persistent and excessive worry that can interfere with daily activities. Symptoms can range from restlessness and irritability to physical issues like rapid heartbeat and muscle tension. Traditional treatments include therapy and medication, but these may not be effective for everyone, prompting some to seek alternative treatments like ayahuasca.
How Ayahuasca Works
Ayahuasca is a powerful plant medicine that contains DMT and harmalines, which interact with the brainās neurotransmitters. This interaction can lead to altered states of consciousness, providing deep introspective experiences and emotional releases.
Emotional and Psychological Healing
One of the most profound effects of ayahuasca is its ability to facilitate emotional and psychological healing. During ceremonies, participants often confront and process deep-seated emotions and traumas. This process can help alleviate anxiety by allowing individuals to release pent-up feelings and gain new perspectives on their worries.
Neuroplasticity and Brain Health
Research suggests that ayahuasca may promote neuroplasticityāthe brainās ability to form new neural connections. This can be particularly beneficial for individuals with anxiety, as it can help in breaking negative thought patterns and fostering healthier ways of thinking and reacting to stressors.
Gaining Insight and Perspective
Ayahuasca can provide profound insights into the root causes of anxiety. Participants often gain a new perspective on their thoughts, behaviors, and personal challenges. This newfound clarity can be instrumental in understanding and managing anxiety symptoms more effectively.
Spiritual Connection and Grounding
Many people with anxiety feel a deep sense of disconnection and uncertainty. Ayahuasca ceremonies often foster a sense of spiritual connection and grounding, helping individuals to reconnect with their inner selves and find a sense of peace and stability.
Supportive Environment
At LaWayra, we ensure a supportive and compassionate environment for our guests. Our experienced facilitators and shamans guide participants through their journeys, providing care and support before, during, and after the ceremonies. This support is vital for safely navigating the intense experiences that ayahuasca can induce.
Integration for Lasting Change
The benefits of ayahuasca are maximized when the insights gained are integrated into daily life. At LaWayra, we offer guidance and support for integrating these experiences, helping participants to sustain the positive changes and improvements in their mental health.
Important Considerations
Itās important to note that ayahuasca is not a standalone treatment for anxiety or any mental health condition. It should be considered as part of a comprehensive approach that includes professional medical and psychological support. If you or someone you know is struggling with anxiety, please seek help from a mental health professional.
If youāre considering ayahuasca as a potential treatment for anxiety, I encourage you to learn more about the experiences of others who have found relief through this powerful medicine. Visit our Instagram page to hear their stories.
Ready to explore ayahuascaās potential for your mental health? Book your spot here and join us at LaWayra for a transformative and supportive experience.
Warm regards, Sam Believ Founder of LaWayra

Sam Believ is the founder and CEO of LaWayra Ayahuasca Retreat, the best-rated Ayahuasca retreat in South America, with over 520 five-star Google reviews and an overall rating of 5 stars. After his life was transformed by Ayahuasca, he dedicated himself to spreading awareness about this ancestral medicine to help address the mental health crisis. Sam is committed to making Ayahuasca retreats affordable, accessible, and authentic, with a focus on care, integration, and the involvement of indigenous shamans. He is also the host of the Ayahuasca Podcast.